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KMID : 0378119880150010288
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Chungnam Medical Journal
1988 Volume.15 No. 1 p.288 ~ p.294
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The Study for Terminal Deoxynucleotidyl Transferase Activity in Leukemic and Various Cancer Patients
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Abstract
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Author studied that Enzyme Immunoassay method have teen used to identify the cells with Terminal Deoxynucleotidyl Transferase (TdT) activity in extracts of whole blood from 80 patients.
The results are as follows
1) All 20 patients with ALL were TdT positive.
2) ALL 4 patients with ALL in remission were TdT negative.
3) 14 cases of 16 patients with ALL were TdT negative.
4) 1 patient with CML in blast crisis was TdT positive.
5) All 6 patients with lymphoma were TdT negative.
6) 6 cases of 30 patients with other disease were TdT positive.
As a result of above study, TdT activity has been proposed as a biological marker for confireming the diagnosis of ALL, for monitoring leuckemic activity during chemotherapy, and for diagnosis of CML in blastic crisis.
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